NJ Weight Loss & Preventive Care

CJC-1295

Patient Education Guide — What It Does, Why a Physician Would Prescribe It, and What the Evidence Says

NJ Weight Loss & Preventive Care Clinics PA
Physician's Offices: 420 Route 46 East Fairfield NJ 07004 & 1605 E Evesham Road Voorhees NJ 08043
(908) 598-0509  |  Jbock@njweightloss.us

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Important Disclaimer — Read Before Using This Page

This information is not intended for use by unlicensed individuals or by licensed professionals who lack adequate training and experience in assessing patients for peptide or hormone therapy. All clinical decisions and dosing must be made in consultation with a licensed, experienced physician and a licensed, experienced compounding pharmacist, and should be supported by published clinical studies.

The information presented here has been compiled using Artificial Intelligence, statements from videos and websites by apparent qualified professionals, and available published research. We strongly encourage exhaustive independent research before considering any therapy. Anyone starting a medication they have never taken before should take an extremely conservative approach.

Nothing on this page or in these videos should be taken as medical advice. These materials are provided only to help begin your research. All dosing and treatment decisions should be made between you and your medical providers after proper evaluation. We are not affiliated with any of the doctors whose videos appear on this page.

CJC-1295 Compounded

Also known as: CJC-1295 with DAC; CJC-1295 without DAC (Mod GRF 1-29)
Category: Growth Hormone Support — GHRH Analog

How it works. CJC-1295 is a synthetic analog built on the first 29 amino acids of growth hormone-releasing hormone—the sequence that carries GHRH's biological activity. Natural GHRH is broken down within minutes; CJC-1295 is modified to resist that breakdown. By mimicking the GHRH signal, it prompts the pituitary to secrete growth hormone in a pulsatile pattern rather than flooding the body with synthetic GH, which means the endogenous feedback system stays intact. It raises both GH and downstream IGF-1.

The one distinction that matters most: DAC vs. no DAC. CJC-1295 with DAC (Drug Affinity Complex) binds to albumin in the bloodstream, extending its half-life to roughly 6–8 days and producing sustained GH and IGF-1 elevation from one or two injections per week. CJC-1295 without DAC—also called Mod GRF 1-29—has a half-life measured in minutes and much more closely mimics the body's natural short pulse. These are not interchangeable products despite sharing a name. The DAC version delivers convenience and higher average GH levels; the no-DAC version preserves natural pulsatility and reduces the risk of GH overshoot, which is why many experienced peptide physicians prefer it. Always confirm which form your prescription is.

Why a physician prescribes it, and what to expect. CJC-1295 is most often prescribed in combination with ipamorelin, because a GHRH signal plus a secretagogue pulse produces a stronger, more physiologic GH release than either alone. It is most defensibly used for selected patients seeking better sleep, faster recovery, lean-mass preservation, and gradual body-composition change—not dramatic transformation. Cautions include cancer history, pituitary disorders, diabetes or insulin resistance, edema, carpal tunnel symptoms, and active sleep apnea. Mild flushing, head rush, vivid dreams, water retention, tingling, or injection-site irritation can occur.

Published Evidence: A 2006 randomized controlled trial (Teichman et al., J Clin Endocrinol Metab) found that CJC-1295 produced dose-dependent increases in GH (2- to 10-fold) and IGF-1 (1.5- to 3-fold) for 6+ days after a single injection, with an estimated half-life of 5.8–8.1 days for the DAC form. After multiple doses, IGF-1 remained elevated for up to 28 days. No serious adverse reactions were reported in that trial.
Key Study: Teichman SL, et al. "Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults." J Clin Endocrinol Metab. 2006;91(3):799-805.

Recommended Videos

Real Dr Explains CJC-1295 + Ipamorelin — The CLASSIC Peptide Stack

Dr. Ashley Froese — This Is Not Covered — Real Dr Explains CJC-1295 + Ipamorelin — The CLASSIC Peptide Stack

CJC-1295, Ipamorelin, Tesamorelin & Sermorelin: Deep Dive on the Best GH Peptides

Quinn Stillson, MD — CJC-1295, Ipamorelin, Tesamorelin & Sermorelin: Deep Dive on the Best GH Peptides

CJC-1295, Ipamorelin, Tesamorelin & Sermorelin: Dosing, Forms, Timing, Frequency & Cycles

Quinn Stillson, MD — CJC-1295, Ipamorelin, Tesamorelin & Sermorelin: Dosing, Forms, Timing, Frequency & Cycles

Video Sources & Independence

The videos linked on this page are provided solely for educational purposes. None of the physicians or channels featured are sponsored by, affiliated with, or compensated by NJ Weight Loss & Preventive Care Clinics, its physicians, or any individuals associated with our practice. We have selected these videos because they offer thoughtful, evidence-based discussion of mechanisms and clinical considerations. Viewers should evaluate all sources independently.

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